BMP-7 protects mesangial cells from injury by polymeric IgA

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Dimeric and polymeric IgA, but not monomeric IgA, enhance the production of IL-6 by human renal mesangial cells

Depositions of IgA in the renal glomerular mesangial area are a hallmark of IgA nephropathy, and are thought to be crucial for the onset of inflammation processes in IgA nephropathy. In this report we show that human mesangial cells (MC) in vitro bind IgA and that binding of IgA enhances the production of IL-6 by MC. Furthermore we show that the size of IgA is crucial in its capability to enhan...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2008

ISSN: 0085-2538

DOI: 10.1038/ki.2008.209